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发表于 2023-6-2 15:47:50
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There are four distinct kindreds with a mutation on chromosome 17 called N279K, and 50 kindreds having a syndrome called FTDP 17 for frontotemporal dementia and parkinsonism Arima et al, 2000; Wszolek and Hutton, 2000, that lumps together 9 different mutations Reed et al, 2000 <a href=http://cial.cfd>buying cialis online reviews</a> While SIN RV and SIN LV are currently used in the clinical setting with considerable success, ex vivo gene therapy still faces multiple challenges that include the 1 extensive ex vivo manipulation of HSPCs required to prepare them for therapeutic use that results in loss of multipotency potential and or reduced fitness for engraftment following transplantation, 2 various conditioning regimens used to enhance engraftment of gene modified HSPCs add considerable genotoxic risks to patients, and 3 requirement of advanced infrastructures for the collection, culture, transduction, validation, and re infusion of HSPCs, consequently restricting this form of treatment to a select few institutions worldwide |
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